Sorting and Secretion of Small RNAs in Exosomes

Parkinson’s Disease Initiative ASAP

Randy Schekman is an investigator of the Howard Hughes Medical Institute and a Professor of Cell and Developmental Biology in the Department of Molecular and Cell Biology at the University of California, at Berkeley. He was awarded the 2013 Nobel Prize in Physiology or Medicine for his role in revealing the machinery that regulates the transport and secretion of proteins in our cells. During the 1970s, Randy Schekman studied yeast cells with malfunctions in their vesicular transport. He demonstrated that the malfunctions were due to genetic defects and explained how different genes regulate different aspects of the transports.

Besides being a Nobel Prize winner, Randy Schekman also received the Albert Lasker Award for Basic Medical Research and Louisa Gross Horwitz Prize of Columbia University, in 2002, for his work on the discovery of machinery regulating vesicle traffic. In 2008, he was named the first Miller Senior Fellow of the Miller Institute at the University of California and, in 2017, received the Golden Plate Award of the American Academy of Achievement.

For the past dozen years, Schekman Labs' has turned to a biochemical analysis of traffic in mammalian cells, including of the pathways of collagen secretion, autophagosome formation, and unconventional secretion. Their current work is focused on the mechanism of extracellular vesicle biogenesis with an emphasis on the means by which exosomes acquire a cell type-specific and highly sorted set of miRNAs.